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What is ITP Awareness Month?

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Image is from Global ITP Awareness Toolkit

Many health conditions affect the daily lives of both people in the United States, and also people around the world. Some conditions are better known such as breast cancer and HIV, while other conditions may not have as much awareness. Blood disorders often fall into this category, as many people are unaware of the serious consequences these cause in patients’ lives.

ITP is one such disorder that often leaves sufferers and families feeling invisible since little is known to the general public and lack of knowledge can even be evident in many medical practices. A lack of visibility makes it difficult for this disease to obtain research funding and limits the treatments available. For this reason, ITP Awareness Month takes on additional importance, bringing public awareness and assets to a lesser known illness.

Understanding How Blood Works

In order to understand how ITP affects people, it is important to first understand how blood works. Blood is made of two primary parts: cells and plasma. The plasma is the liquid, consisting of multiple substances like fats and protein, but is primarily water. The cells are the working pieces, made up of red cells, white cells, and platelets. Red cells carry oxygen while white cells fight infection. Platelets are very tiny cells that work to stop bleeding. If a single part of your blood does not function correctly, it can have an effect on the entire system.

How ITP Affects Platelets

ITP stands for Immune Thrombocytopenia. Implied by the name, ITP is an immune disorder. As with better known immune disorders, this illness causes the body’s immune system to attack healthy cells. In the case of ITP, the healthy cells that are attacked are the body’s platelets. Since platelets are a vital part of clotting, problems with these cells can trigger a range of complications.

People with ITP are prone to bruises and purple spots on the skin. Signs of spontaneous bleeding, most skin conditions are mild. Many ITP patients complain of general fatigue and sometimes depression. More serious problems occur when low platelet counts begin to affect the digestive system, gastrointestinal system, or worse, the brain. Spontaneous hemorrhage caused be platelet deficiency in these areas can lead to serious complications including organ failure and even death.

ITP Treatment

Platelet counts offer a method to monitor, but not treat ITP. Normal counts should range from 150,000 to 400,000 per microliter of blood. ITP patients often have counts closer to 30,000, with a count of 10,000 indicating a serious condition and risk of catastrophic bleed. There is no known cure for ITP, but there are some treatments that have been shown to help treat symptoms and reduce the risk of fatalities.

The Mayo treatment describes the following therapies for ITP.

  • Immune globulin injections that increase blood count.
  • Steroid drugs that suppress the immune system as well as non-steroid immune suppressants.
  • Drugs that boost platelet production.

Severe cases of ITP that do not respond well to the above therapies may require additional treatment such as the surgical removal of the spleen or stronger experimental drugs with harsher side effects.

ITP Awareness Day

By promoting ITP awareness you can do your part to help improve treatments, funding and overall quality of life for those who suffer from ITP. The Platelet Disorder Support Association offers materials and media kits available online.

 

 

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Types and Causes of Kidney Failure

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Image is from Medscape

Your kidneys are one of the most significant organs in the body. They are a pair of organs located towards your lower back and serve the purpose of filtering your blood to remove toxic and waste substances from the body. The toxic substances can be detrimental to your health if they are not removed out of the body.

What is a kidney failure?

Kidney failure is the condition where both of your kidneys or just one of them cannot serve their function to the required level of performance. This can be brought about by a myriad of factors that may interfere with the health and proper function of your kidney. Some of them include:

  • Kidney trauma
  • Some acute and chronic diseases
  • Toxic exposure to environmental pollutants
  • Severe dehydration

When your system is burdened with toxins and dangerous wastes resulting from a kidney failure, what follows are life threatening conditions that can be dangerous to your health. This is the reason why you should always seek the services of a doctor the moment you realize you have a kidney problem.

What causes kidney failure?

The following factors could predispose you to kidney failure

  • Loss of blood flow to the kidney

Kidney failure is often prompted by a sudden loss of blood flow to the kidneys. Some of the diseases and conditions that may lead to loss of blood flow to the kidneys include:

  • Heart attack
  • Severe burn
  • Dehydration
  • Liver failure
  • Allergic reactions
  • Urine elimination problem

When your body finds it difficult to eliminate urine from the system, there is a consequent build up and overloading of the kidneys. Certain cancers can lead to blockage of urine passageways. Such cancers include prostate cancer, cervical cancer, colon cancer, and bladder cancer. Other conditions which that can interfere with urination include

  • Trauma on the nerves controlling urination
  • Blood clots within the urinary tract
  • Kidney stones
  • Enlarged prostate

Other causes

Certain diseases and conditions can lead to kidney failure. They include:

  • A clot of blood in the kidney
  • Drug and alcohol
  • Dyes used in certain imaging tests
  • Chemotherapy drugs (medications that treat autoimmune diseases and cancer)
  • Overload of toxins from heavy metals
  • Thrombotic thrombocytopenic purpura. (A disorder that causes blood clot in tiny vessels)

Types of kidney failure

Below are the types of kidney failure

Acute Prerenal kidney failure

Without enough flow of blood into the kidneys, the kidneys find it difficult to filter out the toxic wastes hence the occurrence of acute perennial kidney failure. This problem is usually solved once the problem leading to the low supply of blood has been determined.

Acute intrinsic kidney failure

Direct trauma causes this kind of kidney failure to either one of the kidneys or both of them. An accident or physical impact can lead to the trauma. Its causes are ischemia and toxic overload making it difficult for the kidney to perform its function in the right manner. Ischemia may be caused by

  • Obstruction of renal blood vessel
  • Shock
  • Severe bleeding
  • Glomerulonephritis

Chronic Prerenal kidney failure

This is the condition where the kidney begins to shrink thus losing its function. The primary cause of this is insufficient blood flowing into the kidneys.

Chronic intrinsic kidney failure

This usually occurs when there is a long-term damage to the kidneys as a result of intrinsic kidney diseases. Direct trauma causes these intrinsic kidney diseases to the kidneys like severe bleeding or insufficient oxygen.

Chronic post renal kidney failure

This is caused by a long-term blockage of the urinary tract thus hindering urination. The consequent is pressure which in turn cause kidney failure.

 

 

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