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pharmacogenomics

The right drug. The right dose. The right time.

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Genes and Drugs

Patients differ in response to drugs. This variation can range from potentially life threatening adverse drug reactions to an equally serious lack of therapeutic efficacy even after taking the standard and safe dose of a drug. As knowledge of the human genome increases, the genetic differences between individuals play an important role in this variability. To help predict potential variability, physicians are increasingly relying on pharmacogenomic testing to provide important clinical information about the genetic status of their patients.

Pharmacogenomics

Pharmacogenomics examines the influence of genetic differences to help understand the clinically relevant variation in drug response. Pharmacogenomic testing applies DNA technology to identify these naturally occurring differences to assist optimization of pharmacotherapy for individual patients. These advances in personalized medicine get the right drug, to the right patient, at the right dose, at the right time.

CYP2D6, CYP3A4/5, & Opioid Metabolism

The ability of a person to metabolize certain opioids is based on the number and functional status of CYP2D6 and CYP3A4/5 genes. Defective genes may lead to impaired metabolism, while gene duplication leads to enhanced drug metabolism. CYP2D6 is characterized with approximately 10% of the population having a slow acting form of this enzyme (poor metabolizer) and 7% a super-fast acting form (ultra metabolizer), and 35% are carriers of a non-functional 2D6 allele. Elevating the risk of ADRs when these individuals are taking multiple drugs.

Cytochrome P450

Cytochrome P450 (CYP) is a set of proteins that help the body metabolize a wide variety of foreign compounds. Certain genetic variants of CYP450 alter the rate of drug metabolism and may cause increased or decreased drug efficacy or adverse drug reactions. In particular, CYP2D6 and CYP3A4/5 are believed to metabolize -30% of all pharmaceuticals. They are known to be essential for metabolism of many commonly prescribed opioids including: codeine, dihydrocodeine, oxycontin, hydrocodone.

Pharmacogenomic Testing for Opioids

Testing provides several clinical benefits:

• Assist physician to make individualized analgesic choice and dose.
• Mitigate regulatory agency scrutiny by providing additional clinical decision making evidence for several schedule II narcotics.

CYP2D6 genotype is one of multiple pieces of information that clinicians should consider in guiding their therapeutic choice for each patient.

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Preemptive Pharmacogenomic Testing

Advancements in medical technology are occurring in the field of DNA testing. Technological advancements are making genomic testing faster and more cost-effective. Now these genotype tests can be done simply through a quick swab of a patient’s cheek and physicians can be analyzing results within a few short days.

These advancements in the field of pharmacogenomics have allowed physicians and pharmacists to select more effective treatment regimens providing more effective as well as safer medicine to their patients.

Not only can medical providers now provide more effective treatment and reduce the possibility of dangerous drug interactions for their patients, providers can also realize the financial benefits of pharmacogenomic testing. This will help the practitioner not only provide more effective medicine but also increase profitability within the practice.

Pharmacogenomic Testing can help Improve Patient Care Through:

  • Cost savings for both patients and providers
  • Help prevent and predict possible dangerous drug interactions
  • Reduce adverse effects from failures in treatment such as hospitalizations
  • Prevent providers from resorting to a “trial-and-error” method of prescribing treatment

Premier Medical Laboratory Services is proud to offer a full panel of pharmacogenomic testing through our MD Genetic Pro program.  Visit our website today to learn more about our testing services. Call us at 877-335-2455 and one of our client services representatives would be happy to help you begin our MD Genetic Pro program!

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How Pharmacogenomics Improves Patient Care

Since 2007, when the FDA acknowledged that a blood-thinning drug’s effectiveness (or lack of) could be determined by how a person’s unique genetic structure responded to dosage, the medical field has been questioning its trial-by-error methodology. Emerging from genetic science, pharmacogenomics is making its way to medical establishments across the nation. This revolutionary field is turning the page to a new and exciting chapter in the healthcare industry. Clients are benefitting from the higher level of expertise medical professionals offer as they bring genetic study into their practices. Research in genomics is revealing how genetic specific application of drugs and dosage can positively trigger better effectiveness in patient prescriptions.

The utilization of Pharmacogenomics (or Pharmacogenetics)  in the medical field brings the commodity of customization to your patients. Pharmacogenomics provides medical professionals with in-depth information based on a patient’s specific gene structure to determine the medication that best suits their needs. The field of pharmacogenetics is rapidly growing. As it gains momentum so does its potential to address a wide range of health issues. Physicians who continually stay informed and up-to-date on the newest discoveries in healthcare offer their clients something often in short supply, hope. The mystery of the human genome is becoming a valuable asset to those immersed in the medical profession.

Why include pharmacogenomics in your practice?

  • They address polymorphisms, genetic variants that can affect your patients’ responses to medications.
  • If you can identify the genetic makeup of each individual client, you may be able to reduce or prevent adverse reactions (due to medication) from occurring.
  • The field of genetics offers physicians more accuracy in terms of writing focused and accurate prescriptions.
  • You can customize a patient’s health regimen around their specific genetics and bring them a more in-depth and detailed health plan.
  • The further exploration and incorporation of pharmacogenomics into the medical field inspires growth and in-depth study regarding how genetics can affect those who suffer from physical or mental disorders.
  • The more you know, the more your clients trust your skillset and feel confident in your abilities.

Customized Care

Almost 50 percent of adverse reactions to medications are caused by genetic variants. It’s an alarming statistic. In the United States the vast majority of hospitalized patient fatalities are credited to negative responses to prescribed medications. If you can correctly predict if a patient has polymorphisms, you can recommend medication that will be effective rather than counterproductive. Pharmacogenetic testing has already been utilized in clinical cases regarding cancer treatment or applied toward those affected by the human immunodeficiency virus.

Patient dissatisfaction arises when those in your care feel they are not being informed on the various treatment options they may have at their disposal. They tend to feel disengaged when healthcare professionals provide only the basic information for self-care and treatment options. To bring encouragement and reduce client anxiety, doctors and nurses can support their clients by exhibiting better communication skills. Offering each individual a list of options or patient applicable developments in the medical field brings much needed peace of mind to those in your care. When you incorporate pharmacogenomics into your medical practice, you are giving your patients a customized experience. Pharmacogenomics is the next step towards providing consistent effective and focused personalized care.

You can read more about Pharmacogenomics here.

Families in Canada order more medicines per man than any other area. The variety of medications marketed by companies is no doubt a contributing matter to prescription preparation abuse epidemic. Various remedies are used to treat Bladder combustion. Certainly it isn’t all. Kamagra is a medicament set to treat many upsets. What do you think about https://levitra-cost.com/levitra-20-mg.html? When you order medications like Kamagra you have to remember about levitra 20 mg. More information about Kamagra available at levitra 20mg. Generally, both men and women are afflicted by sexual dysfunctions. At times another disease can cause to emasculation. Preparatory to purchasing Kamagra or other generic, speak to your dispenser if you have any allergies. Talk to your heartiness care professional any changes in libido you have experienced. Online pharmacy is a best way to find a doctor in your area who treats this kind of malfunction.

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